Nature's Lab CoQ10 + Alpha Lipoic Acid + Acetyl L-Carnitine HCI - 60 Capsules

Nature's Lab CoQ10 + Alpha Lipoic Acid + Acetyl L-Carnitine HCl provides three key nutrients that are necessary for energy production in all cells of the body, working together to support heart and cognitive health.*

Each 2 capsule serving of Nature's Lab CoQ10 + Alpha Lipoic Acid + Acetyl L-Carnitine HCl contains:

  • 500 mg - N-Acetyl L-Carnitine HCL
  • 300 mg - Alpha Lipoic Acid
  • 200 mg - Co-Enzyme

Key Benefits

  • Supports Cognitive Health*
  • Supports Energy Production*
  • Supports Cardiovascular Health*
  • Supports Cellular Energy Production*
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Nature's Lab CoQ10 200mg provides 200mg of coenzyyme Q10 in a vegetarian-friendly capsule to support heart and cognitive health.*

Contains: 200 mg - Coenzyme Q10 (CoQ10)

Key Benefits

  • Supports Cellular Energy*
  • Powerful Antioxidant*
  • Supports Heart Health*
  • Supports Brain Health*
  • Anti-Aging Support*
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Science In Every Capsule.


What is CoQ10?

The body's spark plug to its engine

Coenzyme Q10, also known as Ubiquinone, is an essential nutrient used for mitochondrial function. It is found throughout the human body, though it is mostly concentrated in energy-rich regions such as the heart, lungs, liver, kidney and pancreas*. Its primary biochemical action is to be a co-factor as a lipid-soluble carrier in the electron-transport chain (ETC)*. ETC is a group of proteins that transfers electrons through a cell membrane to create a proton gradient that drives ATP production*. ATP is the largest source of energy in the human body; it is the only molecule able to provide energy to muscle fibers to power muscle contractions*. The human body can synthesize this however, as we age, CoQ10 production decreases by 20% every decade after the age of 21*. CoQ10 is a key antioxidant as it located in close proximity to unsaturated lipid chains and is able to act as a primary scavenger of free radicals*.

Key Benefits

  • Supports Cellular Energy*
  • Powerful Antioxidant*
  • Supports Heart Health*
  • Supports Brain Health*
  • Supports Anti-Aging*

What is Alpha Lipoic Acid?

Alpha Lipoic Acid (ALA), also known as thioctic acid, has a primary function of being a co-factor enzyme with the operation of turning nutrients into energy through two primary methods, the glycine cleavage system and the BCKDC complex*. The purpose of these two methods is to turn carbohydrates into energy. Unbound lipoic acid (supplemented) has powerful antioxidant capabilities and even has the ability to reduce the oxidized forms of CoQ10, vitamin C and glutathione*. It also has the ability to function in both water and fat environments in the human body*.

 

Key Benefits

  • Powerful Antioxidant*
  • Supports Cellular Energy*
  • Supports Glucose Metabolism*
  • Works in conjunction with CoQ10*

What is Acetyl L-Carnitine HCL?

L-Carnitine is an important chemical similar to the amino acid carnitine. It plays a key role in increasing mitochondrial efficiency by transferring long chain fatty acids into the mitochondria for fat breakdown and energy generation and maintaining homeostasis for coenzyme A (CoA)*. Acetyl L-Carnitine (ALCAR) has the ability to cross the blood-brain barrier to efficiently support cognitive health*. ALCAR also plays a role as an antioxidant as it can accumulate toxic metabolites (especially organic acids).*

 

Key Benefits

  • Supports Mitochondrial Function*
  • Supports Cognitive Function*
  • Supports Muscular Endurance*
  • Acts as a Powerful Antioxidant*

Want to Hear About the Latest Probiotic for Cardiovascular Health?


What is a Probiotic?

When we think about probiotics, our initial thoughts often lead us to think of gut health. However, probiotics can benefit several biological functions, and studies have shown that with the right Novel Probiotics, you can support cholesterol levels by maintaining proper LDL/HDL ratio (commonly known as cholesterol levels)*. The heart-supporting probiotic named Lactobacillus Plantarum probiotic (L. plantarum) can survive under harsh gastrointestinal tract conditions and supports production of bile salt hydrolase (BSH).* BSH is an enzyme responsible for de-conjunction of bile salts by bacteria, which may lead to the lowering of cholesterol and alterations in energy homeostasis*.

Key Benefits

  • Promotes Healthy Cholesterol Maintenance*
  • Supports Energy Homeostasis*
  • Promotes Circulatory Health*
  • Supports Healthy Digestion*

Nature's Lab Cardio Probiotic features 3 clinically studied probiotics that can help support cardiovascular health.* This product contains 1.2 Billion live CFUs of the following probiotics:

  • L.plantarum KABP™-011
  • L.plantarum KABP™-012
  • L.plantarum KABP™-013

Key benefits

  • Helps maintain cardiovascular function and a healthy circulatory system *
  • Helps maintain cholesterol levels already within normal range*
  • A synergistic blend of three strains with multiple mechanisms associated with heart health*
  • Helps maintain healthy triglyceride levels already within normal range*
  • Clinically studied, patented probiotic strains for promoting heart health*

 

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Nature's Lab Heart Health

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References

CoQ10

  • Shukla S, Dubey KK. CoQ10 a super-vitamin: review on application and biosynthesis. 3 Biotech. 2018 May;8(5):249. doi: 10.1007/s13205-018-1271-6. Epub 2018 May 9. PMID: 29755918; PMCID: PMC5943198.
  • Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011 Jul;3(3):466-7. doi: 10.4103/0975-7406.84471. PMID: 21966175; PMCID: PMC3178961.
  • Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001 Dec;20(6):591-8. doi: 10.1080/07315724.2001.10719063. PMID: 11771674.
  • Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007 Jun;7 Suppl:S41-50. doi: 10.1016/j.mito.2007.02.006. Epub 2007 Mar 16. PMID: 17482888.
  • Shults CW, Flint Beal M, Song D, Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol. 2004 Aug;188(2):491-4. doi: 10.1016/j.expneurol.2004.05.003. PMID: 15246848.
  • Yan J, Fujii K, Yao J, Kishida H, Hosoe K, Sawashita J, Takeda T, Mori M, Higuchi K. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol. 2006 Feb;41(2):130-40. doi: 10.1016/j.exger.2005.11.007. Epub 2006 Jan 4. PMID: 16387461.
  • Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007 Jun;7 Suppl:S34-40. doi: 10.1016/j.mito.2007.02.010. Epub 2007 Mar 16. PMID: 17482527.
  • Acosta MJ, Vazquez Fonseca L, Desbats MA, Cerqua C, Zordan R, Trevisson E, Salviati L. Coenzyme Q biosynthesis in health and disease. Biochim Biophys Acta. 2016 Aug;1857(8):1079-1085. doi: 10.1016/j.bbabio.2016.03.036. Epub 2016 Apr 7. PMID: 27060254.
  • Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta. 1995 May 24;1271(1):195-204. doi: 10.1016/0925-4439(95)00028-3. PMID: 7599208.
  • Barelos IP, Haas RH. CoQ10 and Aging. Biology (Basel). 2019 May 11;8(2):28. doi: 10.3390/biology8020028. PMID: 31083534; PMCID: PMC6627360.
 
Alpha Lipoic Acid
  • Reed LJ. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. J Biol Chem. 2001 Oct 19;276(42):38329-36. doi: 10.1074/jbc.R100026200. Epub 2001 Jul 26. PMID: 11477096.
  • Carreau JP. Biosynthesis of lipoic acid via unsaturated fatty acids. Methods Enzymol. 1979;62:152-8. doi: 10.1016/0076-6879(79)62212-7. PMID: 374970.
  • Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023-39. doi: 10.1016/s0891-5849(97)00371-7. PMID: 9607614.
  • Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W. Lipoic acid biosynthesis defects. J Inherit Metab Dis. 2014 Jul;37(4):553-63. doi: 10.1007/s10545-014-9705-8. Epub 2014 Apr 29. PMID: 24777537.
  • Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JM. Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells. Free Radic Biol Med. 2002 Jul 1;33(1):83-93. doi: 10.1016/s0891-5849(02)00862-6. PMID: 12086686.
  • Kozlov AV, Gille L, Staniek K, Nohl H. Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. Arch Biochem Biophys. 1999 Mar 1;363(1):148-54. doi: 10.1006/abbi.1998.1064. PMID: 10049509.
  • Hermann R, Niebch G, Borbe H, et al. Enantioselective pharmacokinetics and bioavailability of different racemic alpha-lipoic acid formulations in healthy volunteers. Eur J Pharm Sci. 1996;4(3):167-174.
  • Teichert J, Hermann R, Ruus P, Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J Clin Pharmacol. 2003 Nov;43(11):1257-67. doi: 10.1177/0091270003258654. PMID: 14551180.
L-Carnitine
  • Wang S, Xu J, Zheng J, Zhang X, Shao J, Zhao L, Hao J. Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats. Med Sci Monit. 2020 Jan 16;26:e920250. doi: 10.12659/MSM.920250. PMID: 31945029; PMCID: PMC6984015.
  • Ribas GS, Vargas CR, Wajner M. L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. Gene. 2014 Jan 10;533(2):469-76. doi: 10.1016/j.gene.2013.10.017. Epub 2013 Oct 19. PMID: 24148561.
  • Ferreira GC, McKenna MC. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochemical Research. 2017 Jun;42(6):1661-1675. DOI: 10.1007/s11064-017-2288-7.
  • Müller DM, Seim H, Kiess W, Löster H, Richter T. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism. 2002 Nov;51(11):1389-91. doi: 10.1053/meta.2002.35181. PMID: 12404185.
  • White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990 Jun;15(6):597-601. doi: 10.1007/BF00973749. PMID: 2215852.
  • Rebouche CJ. Carnitine. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. 10th ed. Philadelphia: Lippincott, Williams & Wilkins; 2006:537-544.
  • Rebouche CJ. Carnitine. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore; 2014:440-446.
  • Muthuswamy AD, Vedagiri K, Ganesan M, Chinnakannu P. Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid. Clin Chim Acta. 2006 Jun;368(1-2):84-92. doi: 10.1016/j.cca.2005.12.010. Epub 2006 Feb 15. PMID: 16480704.
Probiotics
  • Himanshu Kumar, Seppo Salminen, Hans Verhagen, Ian Rowland, Jim Heimbach, Silvia Bañares, Tony Young, Koji Nomoto, Mélanie Lalonde,
    Novel probiotics and prebiotics: road to the market, 2015, ISSN 0958-1669,
  • Thushara RM, Gangadaran S, Solati Z, Moghadasian MH. Cardiovascular benefits of probiotics: a review of experimental and clinical studies. Food Funct. 2016 Feb;7(2):632-42. doi: 10.1039/c5fo01190f. PMID: 26786971.
  • Fuentes MC, Lajo T, Carrión JM, Cuñé J. Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults. Br J Nutr. 2013 May 28;109(10):1866-72. doi: 10.1017/S000711451200373X. Epub 2012 Sep 28. PMID: 23017585.